Transmissible Spongiform Encephalopathies in the United States
نویسندگان
چکیده
Cover Photomicrograph of lymphoid follicles of the tonsil of a mule deer (Odocoileus he&onus) with chronic wasting disease (CWD). The dark red staining is the prion that is associated with chronic wasting disease. Im-munohistochemical stain with monoclonal antibody 160.
منابع مشابه
Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein.
The transmissible spongiform encephalopathies are a heterogeneous group of fatal neurodegenerative disorders occurring in humans, mink, cats, and ruminant herbivores. The occurrence of novel transmissible spongiform encephalopathies in cattle in the United Kingdom and Europe and in mule deer and elk in parts of the United States has emphasized the need for reliable diagnostic tests with standar...
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Pigs and poultry in the United Kingdom have undeniably been exposed to the bovine spongiform encephalopathy (BSE) agent. They consumed the same ruminant protein that gave rise to the BSE epidemic in cattle, but there has been no evidence of an epidemic in these species. Experimental investigations have shown pigs to be susceptible to infection by multiple parenteral challenge, but resistant to ...
متن کاملHuman transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993–2002
BACKGROUND The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. METHODS From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible spongiform encephalopathies in eleven EUROCJD-consortium countries over the period 1993-2002, as well as variat...
متن کاملThe emergence of bovine spongiform encephalopathy and related diseases.
Since 1986, approximately 170,000 cases of bovine spongiform encephalopathy (BSE) have occurred among approximately one million animals infected by contaminated feed in the United Kingdom. A ruminant feed ban in 1988 resulted in the rapid decline of the epidemic. Transmissible spongiform encephalopathies due to agents indistinguishable from BSE have appeared in small numbers of exotic zoo anima...
متن کاملSpongiform encephalopathies in Cervidae.
The known host range of naturally-occurring transmissible spongiform encephalopathies has expanded in recent years to include wild ruminants. Chronic wasting disease (CWD) occurs in mule deer (Odocoileus hemionus hemionus) and Rocky Mountain elk (Cervus elaphus nelsoni) in Colorado and Wyoming, United States of America. These species belong to the family Cervidae. Cases have occurred primarily ...
متن کاملDe novo generation of a transmissible spongiform encephalopathy by mouse transgenesis.
Most transmissible spongiform encephalopathies arise either spontaneously or by infection. Mutations of PRNP, which encodes the prion protein, PrP, segregate with phenotypically similar diseases. Here we report that moderate overexpression in transgenic mice of mPrP(170N,174T), a mouse PrP with two point mutations that subtly affect the structure of its globular domain, causes a fully penetrant...
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